Peri-hilar cholangiocarcinoma is a malignant disease that originates from the epithelium of the peri-hilar bile ducts. Given the peculiar anatomical location and the need to perform the patient and for the hepato-biliary surgeons. Surgery is the treatment of choice for most patients and involves major hepatectomy associated with biliary tract resection and locoregional lymphadenectomy. In addition, to achieve radical intervention, vascular resections (portal vein and/or hepatic artery) or pancreatico-duodenectomy may be necessary. Such extensive resection required a specific preoperative management in order to improve the safety and reduce the rates of postoperative morbidity that remains high also in referral centers.
