SG Leaders: Varvara A. Kirchner
Dr. Muhammed Rela
Liver transplantation remains the only effective option for the treatment of end-stage liver disease in adult and pediatric populations. With advances in preoperative evaluation, surgical techniques, immunosuppression, and post-transplant management, the outcomes following liver transplantation in pediatric recipients have improved significantly over the past decades and have allowed transplantation of higher acuity pediatric candidates. However, the risk factors for early reoperative complications in the modern era have not been well defined. The current proposal focuses on the study of donor and recipient risk factors that increase the risk of early reoperation (within 1 month) following deceased and living donor liver transplantation in pediatric recipients. We intend to perform a retrospective review of pediatric transplant databases at large-volume Eastern and Western transplant centers. Recipient and donor characteristics, intraoperative and postoperative factors will be analyzed in respect to the need for reoperation, indications for reoperation, as well as graft and recipient survival. Defining risk factors for reoperation following deceased or living donor liver transplantation in pediatric recipients may allow interventions to mitigate specific risk factors with the ultimate improvement in postoperative management and outcomes following liver transplantation in pediatric recipients.
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