SG Leaders: Alfred Kow Wei Chieh (Singapore); Olivier Scatton (France)
Summary: Metastatic lesions to the liver that extend into the biliary system are uncommon, and their clinical and pathological features are unique compared to the common variant that often metastasized to the liver parenchyma. We aim to gather the largest series of IBCRLM in the world to demonstrate the experience and understand the characteristics of this unusual type of CRL metastasis.
Study design: There are around 36 cases reported in the world so far — in the form of case reports and series. There are likely many more cases not reported due to low numbers, etc.
The study group will create a standard data collection set and open this to anyone who might have treated this condition surgically or otherwise.
The entry criteria is histologically proven colorectal carcinoma from the biliary tissue (genetically consistent with the colonic primary). Data collection will focus on clinical presentation, radiological features, pathological features (including markers and IHC), genetic mutations, treatment outcomes, and prognostic predictors.
Scans performed at diagnosis will be required to be reviewed by the study group to ensure consistency in the case selection.
Peri-hilar cholangiocarcinoma is a malignant disease that originates from the epithelium of the peri-hilar bile ducts. Given the peculiar anatomical location and the need to perform major resections, surgery is the treatment of choice for most patients and involves major hepatectomy associated with biliary tract resection and locoregional lymphadenectomy. In addition, to achieve radical intervention, vascular resections (portal vein and/or hepatic artery) or pancreatico-duodenectomy may be necessary. Such extensive resection requires specific preoperative management in order to improve safety and reduce the rates of postoperative morbidity that remains high also in referral centers.
