DDLT-DONOR-Basic Science Study Group
STUDY GROUP LEADERS
Burcin Ekser (Indiana University, USA)
Cristiano Quintini (Cleveland Clinic, USA)
TITLE: Early Allograft Dysfunction (EAD) in Liver Transplantation: Is it Valid Internationally?
The objective is to collect high-quality data from multiple transplant centers located in different countries of the world to verify whether the current EAD definition and current published predictive scores are valid internationally to predict graft failures/outcomes and to define possibly new criteria that will be valid internationally with the inclusion of donor variables (THE ISLS EAD DEFINITION).
Verification of EAD (with its current definition) that is valid internationally to predict early failure after liver transplantation.
Since it will be a multicentric and internationally participated study, the definition will apply to all centers.
• To define possibly new criteria of EAD which will be valid internationally
• To identify whether EAD predicts early (3-months), 1-year, 3-year, and 5-year graft and patient survivals in an international cohort
STUDY DESIGN: Retrospective
PARTICIPANTS: International multi-center
Patients to be included will fulfill the following inclusion criteria and none of the exclusion criteria:
• All patients with de novo liver transplant either from deceased or living donors from January 2010 to December 2019
• Age ≥18 years old
• Combined liver transplant (liver-kidney, liver-pancreas, liver-heart, liver lung, etc)
• Re-Do liver transplants
• Age < 18-year-old